ITGB3BP anticorps (AA 1-177)

N° du produit ABIN7868260

Cet anticorps anti-ITGB3BP Polyclonal Lapin (ABIN7868260) détecte spécifiquement ITGB3BP dans WB, ELISA et IF. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour ITGB3BP anticorps (AA 1-177) (ABIN7868260)

Antigène: ITGB3BP (Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ITGB3BP est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Détail du produit anti-ITGB3BP anticorps

Épitope: AA 1-177

Fonction: CENP-R Antibody / Centromere protein R / ITGB3BP

Purification: Antigen affinity chromatography

Immunogène: An E.coli-derived human recombinant protein (amino acids M1-N177) was used as the immunogen for the CENP-R antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the CENP-R antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the CENP-R antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur ITGB3BP

Antigène: ITGB3BP (Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP))

Autre désignation: CENP-R

Sujet: Centromere protein R is a protein that in humans is encoded by the ITGB3BP gene. This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants.

UniProt: Q13352

Pathways: Neurotrophin Signaling Pathway