IL-18 anticorps (AA 1-193)

N° du produit ABIN7868338

Cet anticorps anti-IL-18 Monoclonal Souris (Clone IL18-4628) (ABIN7868338) détecte spécifiquement IL-18 dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour IL-18 anticorps (AA 1-193) (ABIN7868338)

Antigène: IL-18 (IL18) (Interleukin 18 (IL18))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IL-18 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: IL18-4628

Détail du produit anti-IL-18 anticorps

Épitope: AA 1-193

Fonction: IL-18 Antibody

Purification: Protein A/G affinity

Immunogène: A recombinant partial protein (within amino acids 1-193) from the human protein was used as the immunogen for the IL-18 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the IL-18 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the IL-18 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur IL-18

Antigène: IL-18 (IL18) (Interleukin 18 (IL18))

Autre désignation: IL-18

Sujet: Four structurally related IL-1 receptor ligands have been described. These include three agonists designated IL-1Alpha, IL-1beta and IL-1gamma/IL-18 and a specific receptor antagonist, IL-1RAlpha. IL-1Alpha and IL-1beta play critical roles in the regulation of the immune response and inflammation, serving as activators of T and B lymphocytes and NK (natural killer) cells. IL-18 (also referred to as IL-1gamma) has been shown to augment the secretion of IFN-gamma from T lymphocytes and increase NK cell activity in spleen cells. IL-18 exhibits 19 % and 12 % identity with IL-1Alpha and IL-1beta respectively over the 12 beta-strands of the beta-trefoil fold domain, which is a signature feature of the IL-1 family. The unusual leader sequence of IL-18 may be analogous to the IL-1beta pro-domain which must be cleaved by the serine protease ICE for optimal secretion and biological activity. Originally described as IGIF (IFN-gamma-inducing factor), IL-18 is induced by mouse liver subsequent to challenge with lipopolysaccharide (LPS).

UniProt: Q14116

Pathways: Cellular Response to Molecule of Bacterial Origin, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome