IL20RA anticorps (AA 1-200)

N° du produit ABIN7868585

Cet anticorps Souris Monoclonal détecte spécifiquement IL20RA dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour IL20RA anticorps (AA 1-200) (ABIN7868585)

Antigène: IL20RA (Interleukin 20 Receptor alpha (IL20RA))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IL20RA est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: IL20RA-1752

Détail du produit anti-IL20RA anticorps

Épitope: AA 1-200

Fonction: IL20R alpha Antibody / IL-20 receptor subunit alpha

Purification: Protein A/G affinity

Immunogène: A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the IL20R alpha antibody.

Isotype: IgG2, kappa

Information d'application

Indications d'application: Optimal dilution of the IL20R alpha antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the IL20R alpha antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur IL20RA

Antigène: IL20RA (Interleukin 20 Receptor alpha (IL20RA))

Autre désignation: IL20R alpha

Sujet: The class II cytokine receptor family includes 12 members, 11 of which combine as various heterodimers to transduce signals across the cellular membrane for 27 cytokines. These cytokines are divided into four structurally related groups: six cytokines of the IL-10 family, 17 type I IFNs, one type II IFN and three IFN-l. IL-20 is a member of the IL-10 family of cytokines that has been shown to be upregulated in psoriatic skin. The receptor for IL-20 (IL-20R) exists as a dimer consisting of IL-20Ra and IL-20Rb. IL-20R also functions as a receptor for IL-19, IL-24 and IL-26. It is highly expressed in skin, brain and testis. IL-20, IL-20Ra and IL-20Rb all have higher expression levels in psoriatic lesional (LS) skin than in nonlesional (NL) skin, suggesting a role for these proteins as potential therapeutic targets. IL-20 can induce signal transducer and activator of transcription (Stat) activation through IL-20R.

UniProt: Q9UHF4