Recombinant MSH6 anticorps (AA 1-200)

N° du produit ABIN7868652

L’anticorps anti-MSH6 Monoclonal Lapin est utilisé pour la détection de MSH6 dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour Recombinant MSH6 anticorps (AA 1-200) (ABIN7868652)

Antigène: MSH6 (MutS Homolog 6 (E. Coli) (MSH6))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp MSH6 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: MSH6-13194R

Détail du produit anti-MSH6 anticorps

Épitope: AA 1-200

Fonction: Recombinant GTBP Antibody / G/T mismatch-binding protein / MSH6 (azide and preservative free)

Purification: Protein A affinity

Immunogène: A portion of amino acids 1-200 from human G/T mismatch-binding protein was used as the immunogen for the recombinant GTBP antibody.

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal dilution of the recombinant GTBP antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the recombinant GTBP antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur MSH6

Antigène: MSH6 (MutS Homolog 6 (E. Coli) (MSH6))

Autre désignation: GTBP

Sujet: MSH6, also called GTBP or G/T mismatch-binding protein, is a mismatch repair protein which is deficient in a high proportion of patients with microsatellite instability (MSI-H). It has been suggested that the deficiencies in DNA mismatch repair protein(s) can be seen in some malignancies such as hereditary nonpolyposis colorectal cancer (HNPCC) and endometrial cancer. MSH6 expressed in all proliferating cells participate in repair of base-base mismatch, that occur during DNA replication. Loss of MSH6/GTBP expression leads to an accumulation of DNA replication errors in the proliferating cells, particularly in areas of the genome with short repetitive nucleotide sequences, a phenomenon known as microsatellite instability (MSI). MSH6/GTBP always used as panel with MLH1, MSH2, PMS2, and may be useful to aid in identifying the most probable gene responsible for the MSI.

UniProt: P52701

Pathways: Réparation de l'ADN, Chromatin Binding, Production of Molecular Mediator of Immune Response