PAX4 anticorps (AA 1-200)

N° du produit ABIN7868697

L’anticorps anti-PAX4 Monoclonal Souris est utilisé pour la détection de PAX4 dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour PAX4 anticorps (AA 1-200) (ABIN7868697)

Antigène: PAX4 (Paired Box 4 (PAX4))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PAX4 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: PAX4-7598

Détail du produit anti-PAX4 anticorps

Épitope: AA 1-200

Fonction: PAX4 Antibody / Paired box 4

Purification: Protein A/G affinity

Immunogène: A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the PAX4 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the PAX4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Aliquot the PAX4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur PAX4

Antigène: PAX4 (Paired Box 4 (PAX4))

Autre désignation: PAX4

Sujet: Pax-4 (paired box gene 4) protein influences normal differentiation of Insulinproducing beta cells and influences normal pancreatic islet development. Pax-4 protein is a transcriptional repressor that binds to a common cis element in the Glucagon, Insulin and Somatostatin promoters. Mouse Pax-4 transcript is present in pancreatic islets, and the islet beta cell lines MIN6, beta TC and NIT1. Differentiation of endoderm-derived endocrine pancreas is mediated through Pax-4 and Pax-6. Pax-4 may act as a Pax-6 repressor due to the competition for binding sites and lower transactivation potential of Pax-4. The human Pax-4 gene encodes a deduced 350 amino acid protein that is 80 % identical to the deduced mouse Pax-4 protein.

UniProt: O43316