TFAM anticorps (AA 1-200)

N° du produit ABIN7868774

Cet anticorps Souris Monoclonal détecte spécifiquement TFAM dans WB et IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour TFAM anticorps (AA 1-200) (ABIN7868774)

Antigène: TFAM (Transcription Factor A, Mitochondrial (TFAM))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TFAM est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: TFAM-9713

Détail du produit anti-TFAM anticorps

Épitope: AA 1-200

Fonction: mtTFA Antibody | Mitochondrial transcription factor 1 / TFAM (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: A portion of amino acids 1-200 from human Mitochondrial transcription factor 1 protein was used as the immunogen for the mtTFA antibody.

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal dilution of the mtTFA antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the mtTFA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur TFAM

Antigène: TFAM (Transcription Factor A, Mitochondrial (TFAM))

Autre désignation: mtTFA

Sujet: MtTFA (mitochondrial transcription factor A), also known as mtTF1, TFAM, TCF6 (for transcription factor 6-like1), TCF6L2 and tsHMG, is a nuclear-encoded gene product that is imported into the mitochondria. mtTFA is required for many aspects of mitochondrial biogenesis including the replication and transcription of mitochondrial DNA (mtDNA). In mouse, testis-specific mtTFA is missing the mitochondria targeting sequence and is present in the nucleus rather than the mitochondria. This form of mtTFA is located primarily in the nuclei of elongated spermatids and may be involved in the regulation of gene expression of the haploid male genome. During mouse and human spermatogenesis there is a reduction of mtTFA protein levels and a reduction in mtDNA copy number. These features may provide one of the mechanisms by which paternal mtDNA transmission is prevented. mtTFA has been associated with mitochondrial disorder in humans characterized by ocular myopathy, exercise intolerance and muscle wasting.

UniProt: Q00059

Pathways: Chromatin Binding