FAM60A anticorps (AA 1-221)

N° du produit ABIN7868850

L’anticorps anti-FAM60A Polyclonal Lapin est utilisé pour la détection de FAM60A dans des échantillons de Humain et Rat. Il a été validé pour ELISA, WB, IF, FACS et IHC (p).

Aperçu rapide pour FAM60A anticorps (AA 1-221) (ABIN7868850)

Antigène: FAM60A (Family with Sequence Similarity 60, Member A (FAM60A))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FAM60A est non-conjugé

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-FAM60A anticorps

Épitope: AA 1-221

Fonction: FAM60A Antibody / SINHCAF

Purification: Antigen affinity purified

Immunogène: E. coli-derived recombinant human protein (amino acids M1-W221) was used as the immunogen for the FAM60A antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the FAM60A antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the FAM60A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur FAM60A

Antigène: FAM60A (Family with Sequence Similarity 60, Member A (FAM60A))

Autre désignation: FAM60A

Sujet: FAM60A, also known as Protein FAM60A, Tera protein homolog and SIN3-HDAC complex-associated factor (SINHCAF), is a subunit of the Sin3 deacetylase complex (Sin3/HDAC) that is important for the repression of genes. The SIN3A-HDAC complex deacetylates histones thereby repressing gene transcription. FAM60A specifically impacts genes encoding components of the TGF-beta signaling pathway and promoters of important proteins like cyclin D1. FAM60A activity peaks during G1 and S phases of the cell cycle and is up regulated in many carcinoma and tumor tissues. Additionally, loss of FAM60A leads to a change in cell morphology, an increase in cell migration, increased histone acetylation at the cyclin D1 promoter and elevated levels of cyclin D1 mRNA and protein. Furthermore, depletion of FAM60A altered the periodic association of HDAC1 with the cyclin D1 promoter, increased cyclin D1 expression at all cell cycle phases, and caused premature S phase entry.

UniProt: Q9NP50