NAT15 anticorps (AA 1-242)

N° du produit ABIN7868910

L’anticorps anti-NAT15 Polyclonal Lapin est utilisé pour la détection de NAT15 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, ELISA, IHC, IF, ICC et IP.

Aperçu rapide pour NAT15 anticorps (AA 1-242) (ABIN7868910)

Antigène: NAT15 (N-Acetyltransferase 15 (NAT15))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NAT15 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Détail du produit anti-NAT15 anticorps

Épitope: AA 1-242

Fonction: NAA60 Antibody / N-alpha-acetyltransferase 60

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human NAA60 recombinant protein (Position: M1-M242) was used as the immunogen for the NAA60 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the NAA60 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the NAA60 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur NAT15

Antigène: NAT15 (N-Acetyltransferase 15 (NAT15))

Autre désignation: NAA60

Sujet: NAA60 antibody detects N-alpha-acetyltransferase 60, a Golgi-associated enzyme responsible for acetylating the N-termini of transmembrane and cytosolic proteins. The UniProt recommended name is N-alpha-acetyltransferase 60 (NAA60). This enzyme belongs to the GNAT (GCN5-related N-acetyltransferase) family and contributes to post-translational protein modification, stability, and membrane targeting.

Functionally, NAA60 antibody identifies a 242-amino-acid acetyltransferase localized to the cytosolic face of the Golgi apparatus. NAA60 catalyzes the transfer of an acetyl group from acetyl-CoA to protein N-termini, particularly targeting lysine residues within membrane-bound substrates. Its unique subcellular localization distinguishes it from other N-terminal acetyltransferases (NATs) acting in the cytosol or nucleus.

The NAA60 gene is located on chromosome 16p13.3 and is broadly expressed in mammalian tissues, with enrichment in epithelial and secretory cells. By modifying transmembrane proteins, NAA60 influences vesicle trafficking, protein sorting, and Golgi membrane organization. It also contributes to cell cycle progression and mitotic spindle stability.

Pathologically, altered NAA60 activity has been linked to cell proliferation abnormalities and tumorigenesis. Reduced NAA60 expression affects Golgi morphology and disrupts intracellular transport. Research using NAA60 antibody supports studies in protein acetylation, Golgi biology, and membrane-associated protein regulation.

NAA60 antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect acetyltransferases in cell lysates and subcellular fractions. NSJ Bioreagents provides NAA60 antibody reagents optimized for research in protein modification, trafficking, and cell signaling.

Structurally, N-alpha-acetyltransferase 60 contains a conserved acetyl-CoA-binding motif and catalytic residues typical of GNAT enzymes. This antibody enables investigation of NAA60's functional role in post-translational regulation and Golgi-associated protein processing.

UniProt: Q9H7X0