CD33 anticorps (AA 1-250)

N° du produit ABIN7868933

Cet anticorps Souris Monoclonal détecte spécifiquement CD33 dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour CD33 anticorps (AA 1-250) (ABIN7868933)

Antigène: CD33

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD33 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: SIGLEC3-3597

Détail du produit anti-CD33 anticorps

Épitope: AA 1-250

Fonction: SIGLEC3 Antibody / CD33 (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: A recombinant partial protein sequence (within amino acids 1-250) from the human protein was used as the immunogen for the SIGLEC3 antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the SIGLEC3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the SIGLEC3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur CD33

Antigène: CD33

Autre désignation: SIGLEC3

Sujet: Recognizes a 67 kDa glycoprotein, which is identified as CD33. It is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies, these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.

UniProt: P20138