Prohibitin 2 anticorps (AA 1-299)

N° du produit ABIN7869078

L’anticorps anti-Prohibitin 2 Polyclonal Lapin est utilisé pour la détection de Prohibitin 2 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, ELISA, IHC (p), IF et FACS.

Aperçu rapide pour Prohibitin 2 anticorps (AA 1-299) (ABIN7869078)

Antigène: Prohibitin 2 (PHB2)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Prohibitin 2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Flow Cytometry (FACS)

Détail du produit anti-Prohibitin 2 anticorps

Épitope: AA 1-299

Fonction: PHB2 Antibody / Prohibitin 2

Purification: Affinity purified

Immunogène: Recombinant human protein (amino acids M1-K299) was used as the immunogen for the PHB2 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the PHB2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the PHB2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur Prohibitin 2

Antigène: Prohibitin 2 (PHB2)

Autre désignation: PHB2

Sujet: PHB2 (Prohibitin 2), also called Repressor of Estrogen Receptor Activity (REA), is a protein that in humans is encoded by the PHB2 gene. The International Radiation Hybrid Mapping Consortium mapped the PHB2 gene to chromosome 12. Montano et al.(1999) showed that REA enhanced the potency of a dominant-negative ER-alpha mutant and antiestrogens as suppressors of ER-alpha activity in Chinese hamster ovary cells. When coexpressed with wildtype ER-alpha or ER-beta(ESR2), REA suppressed activation of a reporter gene in a dose-dependent manner. REA had no effect on reporter activity in the absence of liganded ER, and it had no effect on the transcriptional activities of other hormone receptors. Mutation analysis showed that an N-terminal domain and a central domain of REA were required for its repressor activity.

UniProt: Q99623

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling