Beclin 1 anticorps (AA 1-354)

N° du produit ABIN7869243

L’anticorps anti-Beclin 1 Monoclonal Souris est utilisé pour la détection de Beclin 1 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, IF, FACS et IHC (p).

Aperçu rapide pour Beclin 1 anticorps (AA 1-354) (ABIN7869243)

Antigène: Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Beclin 1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 2D12A3

Détail du produit anti-Beclin 1 anticorps

Épitope: AA 1-354

Fonction: BECN1 Antibody / Beclin 1

Purification: Antigen affinity purified

Immunogène: Recombinant human protein (amino acids M1-S354) was used as the immunogen for the BECN1 antibody.

Isotype: IgG1

Information d'application

Indications d'application: Optimal dilution of the BECN1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the BECN1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur Beclin 1

Antigène: Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Autre désignation: BECN1

Sujet: Beclin-1, also known as also known as ATG6 or VPS30 is a protein that in humans is encoded by the BECN1 gene. Beclin-1 and its binding partner class III phosphoinositide 3-kinase (PI3K), also named Vps34, are required for the initiation of the formation of the autophagosome in autophagy. This gene participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. Schizophrenia is associated with low levels of Beclin-1 in the hippocampus of the affected which causes diminished autophagywhich in turn results in increased neuronal cell death. It has been found that beclin-1 can promote autophagy in autophagy-defective yeast with a targeted disruption of apg6/vps30, and in human MCF7 breast carcinoma cells.

UniProt: Q14457

Pathways: Autophagy