Recombinant NKX2-1 anticorps (AA 1-400)

N° du produit ABIN7869315

L’anticorps anti-NKX2-1 Monoclonal Lapin est utilisé pour la détection de NKX2-1 dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour Recombinant NKX2-1 anticorps (AA 1-400) (ABIN7869315)

Antigène: NKX2-1 (NK2 Homeobox 1 (NKX2-1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp NKX2-1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: TTF1-8143R

Détail du produit anti-NKX2-1 anticorps

Épitope: AA 1-400

Fonction: NKX2.1 Antibody / TTF-1

Purification: Protein A/G affinity

Immunogène: A recombinant partial protein sequence (within amino acids 1-400) from the human protein was used as the immunogen for the NKX2.1 antibody.

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal dilution of the NKX2.1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the NKX2.1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur NKX2-1

Antigène: NKX2-1 (NK2 Homeobox 1 (NKX2-1))

Autre désignation: NKX2.1

Sujet: Recognizes a protein of 40 kDa, identified as Thyroid transcription factor-1 (TTF-1). TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates.Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.

UniProt: P43699

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Systemic Arterial Blood Pressure by Hormones, Cellular Glucan Metabolic Process, Feeding Behaviour