APC anticorps (AA 1-433)

N° du produit ABIN7869357

L’anticorps anti-APC Monoclonal Souris est utilisé pour la détection de APC dans des échantillons de Humain. Il a été validé pour WB, IF et FACS.

Aperçu rapide pour APC anticorps (AA 1-433) (ABIN7869357)

Antigène: APC (Adenomatous Polyposis Coli (APC))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp APC est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: ALi 12-28

Détail du produit anti-APC anticorps

Épitope: AA 1-433

Fonction: Adenomatous polyposis coli Antibody / APC

Purification: Protein G affinity chromatography

Immunogène: A recombinant human partial protein (amino acids 1-433) was used as the immunogen for the Adenomatous polyposis coli antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the Adenomatous polyposis coli antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Adenomatous polyposis coli antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur APC

Antigène: APC (Adenomatous Polyposis Coli (APC))

Autre désignation: Adenomatous polyposis coli

Sujet: The adenomatous polyposis syndromes, familial adenomatous polyposis (FAP) and Gardner's syndrome (GS), are characterized by numerous adenomatous polyps throughout the entire colon. These polyps invariably progress to colon cancer in addition to other extracolonic manifestations. The cloning of the APC gene revealed a ubiquitously expressed protein, 2,843 amino acids in length, which is frequently mutated in patients suffering from FAP and GS. APC has been found to be associated with structural components of intracellular junctions. Functions as a tumor suppressor, promoting rapid degradation of CTNNB1 and is a negative regulator of Wnt signaling. Also plays a role in HGF-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.

UniProt: P25054

Pathways: Signalisation WNT, Stem Cell Maintenance, Cell-Cell Junction Organization