PPARG anticorps (AA 1-512)

N° du produit ABIN7869446

Cet anticorps Lapin Polyclonal détecte spécifiquement PPARG dans WB. Il présente une réactivité avec des échantillons de Poisson zèbre (Danio rerio).

Aperçu rapide pour PPARG anticorps (AA 1-512) (ABIN7869446)

Antigène: PPARG (Peroxisome Proliferator-Activated Receptor gamma (PPARG))

Reactivité: Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PPARG est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PPARG anticorps

Épitope: AA 1-512

Fonction: Zebrafish Ppar gamma Antibody / Pparg

Purification: Antigen affinity chromatography

Immunogène: E. coli-derived zebrafish Ppar gamma recombinant protein (amino acids M1-D512) was used as the immunogen for the Zebrafish Ppar gamma antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal dilution of the Zebrafish Ppar gamma antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the Zebrafish Ppar gamma antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur PPARG

Antigène: PPARG (Peroxisome Proliferator-Activated Receptor gamma (PPARG))

Autre désignation: Ppar gamma

Sujet: Pparg (Peroxisome proliferator-activated receptor gamma) is a critical transcription factor that belongs to the nuclear receptor superfamily. It plays a vital role in regulating lipid metabolism, glucose homeostasis, inflammation, and adipocyte differentiation. As a ligand-activated transcription factor, Pparg regulates the expression of genes involved in a variety of physiological processes, including energy metabolism, insulin sensitivity, and immune response. Pparg is activated by fatty acids and other lipid metabolites, making it a key regulator of metabolic homeostasis.

In zebrafish, Pparg is an ortholog of the human PPARG gene. The zebrafish and human proteins share a high degree of sequence conservation, particularly in their DNA binding domain and ligand-binding domain, which are essential for their function as transcription factors. This evolutionary conservation suggests that the role of Pparg in regulating lipid metabolism and adipogenesis is preserved across species, making zebrafish a valuable model for studying the molecular mechanisms of metabolic diseases and obesity.

Pparg in zebrafish has isoforms, which may exhibit tissue-specific expression and functional variation. The existence of isoforms allows for regulation of different target genes depending on developmental stages, tissue types, and environmental conditions. These isoforms may also be involved in regulating distinct physiological processes, such as fatty acid metabolism, inflammatory response, and immune cell differentiation.

In zebrafish, Pparg is expressed in various tissues, including the adipose tissue, liver, and muscles, as well as in developing embryos. Its expression is tightly regulated to ensure proper energy homeostasis and organ development. Pparg plays an essential role in early development, especially in regulating the formation of adipocytes (fat cells), which are important for long-term energy storage and regulation. Disruption of Pparg function in zebrafish can result in defects in lipid metabolism and adipogenesis, providing a model for studying metabolic disorders.

UniProt: A6XMH6

Pathways: Signalisation MAPK, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Endopeptidase Activity, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation