ME1 anticorps (AA 1-572)

N° du produit ABIN7869481

Cet anticorps anti-ME1 Polyclonal Lapin (ABIN7869481) détecte spécifiquement ME1 dans WB, IF, IHC (p) et FACS. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour ME1 anticorps (AA 1-572) (ABIN7869481)

Antigène: ME1 (Malic Enzyme 1, NADP(+)-Dependent, Cytosolic (ME1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ME1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Détail du produit anti-ME1 anticorps

Épitope: AA 1-572

Fonction: ME1 Antibody / Malic enzyme 1

Purification: Antigen affinity purified

Immunogène: Recombinant human protein (amino acids M1-Q572) was used as the immunogen for the ME1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the ME1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the ME1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur ME1

Antigène: ME1 (Malic Enzyme 1, NADP(+)-Dependent, Cytosolic (ME1))

Autre désignation: ME1

Sujet: ME1 (Malic enzyme 1) is a cytosolic enzyme that catalyzes the oxidative decarboxylation of malate to pyruvate, producing NADPH in the process. This reaction plays a critical role in cellular metabolism by linking the tricarboxylic acid (TCA) cycle to lipid biosynthesis and antioxidant defense. ME1-derived NADPH is essential for fatty acid and cholesterol synthesis, as well as for maintaining redox balance in cells.

ME1 is expressed in various tissues, with particularly high levels in lipogenic tissues such as liver, adipose tissue, and lactating mammary gland. Its activity is regulated by nutritional and hormonal signals, including carbohydrate intake and insulin, making it a key player in metabolic adaptation. Due to its involvement in energy metabolism and biosynthetic processes, ME1 has been widely studied in the contexts of metabolic regulation and biochemical pathway integration.

The ME1 antibody is a valuable reagent for detecting ME1 in research applications such as western blot, immunohistochemistry, and immunofluorescence. Researchers use the ME1 antibody from NSJ Bioreagents to assess tissue-specific expression, study its role in lipid metabolism, and investigate its contribution to NADPH production. With strong specificity and reproducible performance, the ME1 antibody supports a wide range of studies in cellular metabolism, enzymology, and biochemical research.

UniProt: P48163

Pathways: Regulation of Lipid Metabolism by PPARalpha