Dystrobrevin beta anticorps (AA 1-627)

N° du produit ABIN7869507

L’anticorps anti-Dystrobrevin beta Polyclonal Lapin est utilisé pour la détection de Dystrobrevin beta dans des échantillons de Humain, Rat et Souris. Il a été validé pour WB, ELISA et FACS.

Aperçu rapide pour Dystrobrevin beta anticorps (AA 1-627) (ABIN7869507)

Antigène: Dystrobrevin beta (DTNB) (Dystrobrevin, beta (DTNB))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Dystrobrevin beta est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Détail du produit anti-Dystrobrevin beta anticorps

Épitope: AA 1-627

Fonction: DTNB Antibody / Dystrobrevin beta

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human DTNB recombinant protein (Position: M1-G627) was used as the immunogen for the DTNB antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the DTNB antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the DTNB antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur Dystrobrevin beta

Antigène: Dystrobrevin beta (DTNB) (Dystrobrevin, beta (DTNB))

Autre désignation: DTNB

Sujet: DTNB antibody detects Dystrobrevin beta, a cytoplasmic scaffolding protein that associates with dystrophin and syntrophin complexes at the plasma membrane. DTNB participates in maintaining membrane stability, signal transduction, and cytoskeletal anchoring in muscle and neuronal tissues. The DTNB antibody is widely used in muscle biology, neuroscience, and membrane research to study dystrophin-associated complexes and neuromuscular organization.

DTNB is encoded by the DTNB gene located on human chromosome 2p16.2. The protein is approximately 628 amino acids in length and shares structural similarity with dystrobrevin alpha. DTNB localizes to the cytoplasmic face of the sarcolemma and interacts with dystrophin, syntrophins, and other adaptor proteins within the dystrophin-glycoprotein complex (DGC), which links the cytoskeleton to the extracellular matrix.

The DTNB antibody detects a 70 kilodalton protein by western blot and reveals sarcolemmal and cytoplasmic localization under immunofluorescence microscopy. In skeletal muscle, DTNB contributes to stabilization of muscle fibers and transmission of mechanical force. In neurons, it participates in postsynaptic density organization and signal transduction, influencing synaptic plasticity and neurotransmission.

Dysfunction or loss of DTNB disrupts DGC integrity, leading to impaired muscle contractility and signaling abnormalities. Variants in DTNB have been associated with neuromuscular diseases, cognitive deficits, and cardiomyopathy. Through its scaffolding functions, DTNB regulates localization of signaling molecules such as nitric oxide synthase and kinases involved in muscle adaptation.

Because of its role in linking the cytoskeleton to membrane signaling complexes, DTNB provides insights into muscular dystrophy mechanisms and synaptic organization. NSJ Bioreagents provides a validated DTNB antibody optimized for its applications, supporting research into muscle integrity, neuronal communication, and cytoskeletal scaffolding.

UniProt: O60941