ube3a anticorps (AA 1-860)

N° du produit ABIN7869597

L’anticorps anti-ube3a Monoclonal Souris est utilisé pour la détection de ube3a dans des échantillons de Humain et Singe. Il a été validé pour WB et FACS.

Aperçu rapide pour ube3a anticorps (AA 1-860) (ABIN7869597)

Antigène: ube3a (Ubiquitin Protein Ligase E3A (ube3a))

Reactivité: Humain, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ube3a est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: 3F13

Détail du produit anti-ube3a anticorps

Épitope: AA 1-860

Fonction: UBE3A Antibody / Ubiquitin-protein ligase E3A

Purification: Affinity purified

Immunogène: A human recombinant partial protein (amino acids M1-E860) was used as the immunogen for the UBE3A antibody.

Isotype: IgG2b

Information d'application

Indications d'application: Optimal dilution of the UBE3A antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the UBE3A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur ube3a

Antigène: ube3a (Ubiquitin Protein Ligase E3A (ube3a))

Autre désignation: UBE3A

Sujet: Ubiquitin-protein ligase E3A (UBE3A) also known as E6AP ubiquitin-protein ligase (E6AP) is an enzyme that in humans is encoded by the UBE3A gene. It is mapped to 15q11.2. This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.

UniProt: Q05086

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway