SMC1B anticorps (AA 106-1221)

N° du produit ABIN7869992

Cet anticorps Lapin Polyclonal détecte spécifiquement SMC1B dans WB, ELISA, IF et ICC. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour SMC1B anticorps (AA 106-1221) (ABIN7869992)

Antigène: SMC1B (Structural Maintenance of Chromosomes 1B (SMC1B))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMC1B est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Détail du produit anti-SMC1B anticorps

Épitope: AA 106-1221

Fonction: SMC1B Antibody / Structural maintenance of chromosomes protein 1B

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human SMC1B recombinant protein (Position: R106-D1221) was used as the immunogen for the SMC1B antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the SMC1B antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the SMC1B antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur SMC1B

Antigène: SMC1B (Structural Maintenance of Chromosomes 1B (SMC1B))

Autre désignation: SMC1B

Sujet: SMC1B antibody detects Structural maintenance of chromosomes protein 1B, a cohesin complex component essential for chromosome cohesion during meiosis. Encoded by the SMC1B gene on chromosome 22q13.33, this protein is a meiosis-specific paralog of the somatic cohesin subunit SMC1A. SMC1B forms part of the cohesin ring complex that links sister chromatids and facilitates homologous recombination and synapsis. It ensures accurate chromosome segregation and genomic integrity in germ cells, playing a critical role in gametogenesis and fertility.

SMC1B forms heterodimers with SMC3 and associates with meiosis-specific cohesin components such as REC8, STAG3, and RAD21L. Together, these proteins establish and maintain cohesion between homologous chromosomes from prophase I until anaphase I, preventing premature separation. SMC1B also contributes to chromatin organization, double-strand break repair, and gene regulation during meiosis. Its expression is restricted mainly to germ cells in the testes and ovaries, though low levels may be detected in certain somatic tissues under specific developmental conditions.

The SMC1B antibody is used in cell biology, reproductive, and chromatin research to investigate cohesin complex formation and meiotic chromosome dynamics. Western blot analysis identifies a 145 kilodalton band corresponding to SMC1B, while immunofluorescence reveals chromosomal axis localization in meiotic cells. This antibody supports studies of meiotic cohesion, synaptonemal complex assembly, and chromosomal recombination.

Deficiency or mutation of SMC1B disrupts chromosome pairing and leads to infertility, meiotic arrest, or aneuploidy. Beyond meiosis, SMC1B may contribute to chromatin architecture and DNA repair in somatic cells. The SMC1B antibody provides a powerful tool for characterizing cohesin-mediated chromosome interactions and meiotic mechanisms. NSJ Bioreagents supplies this antibody validated for western blotting and immunofluorescence, ensuring reliable performance in chromosomal cohesion and germ cell research.

UniProt: Q8NDV3