Mannose Receptor anticorps (AA 1100-1400)

N° du produit ABIN7870106

Cet anticorps Souris Monoclonal détecte spécifiquement Mannose Receptor dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Mannose Receptor anticorps (AA 1100-1400) (ABIN7870106)

Antigène: Mannose Receptor (MR)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Mannose Receptor est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: MRC1-9457

Détail du produit anti-Mannose Receptor anticorps

Épitope: AA 1100-1400

Fonction: Mannose Receptor Antibody / MRC1 / CD206

Purification: Protein G affinity

Immunogène: A portion of amino acids 1100-1400 from human Macrophage mannose receptor 1 protein was used as the immunogen for the Mannose Receptor antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the Mannose Receptor antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Mannose Receptor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur Mannose Receptor

Antigène: Mannose Receptor (MR)

Autre désignation: Mannose Receptor

Sujet: CD206, also known as macrophage mannose receptor type C (MMR, MRC1L1 and MRC1), is a type I membrane receptor protein. It is an phagocytic and endocytic receptor that can recognize carbohydrate ligands in target molecules. The extracellular portion of the protein includes eight C-type carbohydrate recognition domains (CRD) which are clustered together to achieve higher affinity binding to saccharides. CD206 is found on macrophages and on endothelial cells of the liver and is the only known example of a C-type lectin that contains multiple C-type CRDs. CD206 mediates the endocytosis of glycoproteins by macrophages and binds high-mannose structures on the surface of potentially pathogenic viruses, fungi and bacteria enabling them to be neutralized by phagocytic engulfment. During inflammation, CD206 is crucial for rapid clearance of several mannose-bearing serum glycoproteins but does not regulate the initiation of inflammation. CD206 is primarily expressed in mature tissue macrophages and immature dendritic cells, as well as hepatic and lymphatic endothelial cells, retinal pigmental epithelium (RPE) and mesangial cells.

UniProt: P22897