IL1A anticorps (AA 113-271)

N° du produit ABIN7870147

Cet anticorps anti-IL1A Monoclonal Souris (Clone IL1A-3982) (ABIN7870147) détecte spécifiquement IL1A dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour IL1A anticorps (AA 113-271) (ABIN7870147)

Antigène: IL1A (Interleukin 1 alpha (IL1A))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IL1A est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: IL1A-3982

Détail du produit anti-IL1A anticorps

Épitope: AA 113-271

Fonction: IL-1 alpha Antibody / IL1A (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogène: A portion of amino acids 113-271 from the human protein was used as the immunogen for the IL-1 alpha antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the IL-1 alpha antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the IL-1 alpha antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur IL1A

Antigène: IL1A (Interleukin 1 alpha (IL1A))

Autre désignation: IL-1 alpha

Sujet: Two forms of interleukin-1, designated IL-1 alpha and beta, have been described. Although encoded by distinct genes and exhibiting roughly only 25 % sequence identity, IL-1a and IL-1b bind to the same receptor and seem to elicit similar biological responses. IL-1 production is generally thought to be associated with inflammation, but it has also been shown to be expressed during kidney development, thymocyte differentiation and cartilage degradation. IL-1 plays a critical role in the regulation of immune response and inflammation, acting as an activator of T and B lymphocytes and natural killer (NK) cells. In T cells, IL-1 stimulates the production of IL-2 and selectively inhibits IL-4 expression. IL-1 induces B cell proliferation and maturation, and immunoglobulin synthesis. NK cells require IL-1 for production of the anti-pathogen IFN-. IL-1 has also been implicated in several pathological conditions including rheumatoid arthritis, inflammatory bowel disease and atherosclerosis.

UniProt: P01583

Pathways: Signalisation NF-kappaB, Autophagy, Cancer Immune Checkpoints