Dystrophin anticorps (AA 114-263)

N° du produit ABIN7870169

Cet anticorps Souris Monoclonal détecte spécifiquement Dystrophin dans ELISA et IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Dystrophin anticorps (AA 114-263) (ABIN7870169)

Antigène: Dystrophin (DMD)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Dystrophin est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: DMD-3676

Détail du produit anti-Dystrophin anticorps

Épitope: AA 114-263

Fonction: DMD Antibody / Dystrophin (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: A portion of amino acids 114-263 from the human protein was used as the immunogen for the DMD antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the DMD antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the DMD antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur Dystrophin

Antigène: Dystrophin (DMD)

Autre désignation: DMD

Sujet: Dystrophin-glycoprotein complex (DGC) connects the F-Actin cytoskeleton on the inner surface of muscle fibers to the surrounding extracellular matrix, through the cell membrane interface. A deficiency in this protein contributes to Duchenne (DMD) and Becker (BMD) muscular dystrophies. The human dystrophin gene measures 2.4 megabases, has more than 80 exons, produces a 14 kb mRNA and contains at least 8 independent tissue-specific promoters and 2 poly A sites. The dystrophin mRNA can undergo differential splicing and produce a range of transcripts that encode a large set of proteins. Dystrophin represents approximately 0.002 % of total striated muscle protein and localizes to triadic junctions in skeletal muscle, where it is thought to influence calcium ion homeostasis and force transmission.

UniProt: P11532

Pathways: Skeletal Muscle Fiber Development