Dystrophin anticorps (AA 114-263)

N° du produit ABIN7870175

Cet anticorps Souris Monoclonal détecte spécifiquement Dystrophin dans ELISA et IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Dystrophin anticorps (AA 114-263) (ABIN7870175)

Antigène: Dystrophin (DMD)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Dystrophin est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: DMD-3243

Détail du produit anti-Dystrophin anticorps

Épitope: AA 114-263

Fonction: Dystrophin Antibody / DMD

Purification: Protein G affinity chromatography

Immunogène: Amino acids 114-263 from the human protein were used as the immunogen for the Dystrophin antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the Dystrophin antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Dystrophin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur Dystrophin

Antigène: Dystrophin (DMD)

Autre désignation: Dystrophin

Sujet: Dystrophin-glycoprotein complex (DGC) connects the F-Actin cytoskeleton on the inner surface of muscle fibers to the surrounding extracellular matrix, through the cell membrane interface. A deficiency in this protein contributes to Duchenne (DMD) and Becker (BMD) muscular dystrophies. The human dystrophin gene measures 2.4 megabases, has more than 80 exons, produces a 14 kb mRNA and contains at least 8 independent tissue-specific promoters and 2 poly A sites. The dystrophin mRNA can undergo differential splicing and produce a range of transcripts that encode a large set of proteins. Dystrophin represents approximately 0.002 % of total striated muscle protein and localizes to triadic junctions in skeletal muscle, where it is thought to influence calcium ion homeostasis and force transmission.

UniProt: P11532

Pathways: Skeletal Muscle Fiber Development