ARNTL anticorps (AA 116-447)

N° du produit ABIN7870238

Cet anticorps Lapin Polyclonal détecte spécifiquement ARNTL dans WB et ELISA. Il présente une réactivité avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour ARNTL anticorps (AA 116-447) (ABIN7870238)

Antigène: ARNTL (Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ARNTL est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-ARNTL anticorps

Épitope: AA 116-447

Fonction: BMAL1 Antibody

Purification: Affinity purified

Immunogène: A human recombinant protein (amino acids R116-E447) was used as the immunogen for the BMAL1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the BMAL1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the BMAL1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur ARNTL

Antigène: ARNTL (Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL))

Autre désignation: BMAL1

Sujet: Aryl hydrocarbon receptor nuclear translocator-like protein 1 is protein that in humans is encoded by the ARNTL gene. The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene.

UniProt: O00327

Pathways: Regulation of Lipid Metabolism by PPARalpha, Protein targeting to Nucleus, L'effet Warburg