Recombinant Topoisomerase II alpha anticorps (AA 1300-1500)

N° du produit ABIN7870497

L’anticorps anti-Topoisomerase II alpha Monoclonal Souris est utilisé pour la détection de Topoisomerase II alpha dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour Recombinant Topoisomerase II alpha anticorps (AA 1300-1500) (ABIN7870497)

Antigène: Topoisomerase II alpha (TOP2A) (Topoisomerase (DNA) II alpha 170kDa (TOP2A))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Topoisomerase II alpha est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: RTOP2A-8339

Détail du produit anti-Topoisomerase II alpha anticorps

Épitope: AA 1300-1500

Fonction: Recombinant TOP2A Antibody / Topoisomerase II alpha (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: A recombinant human Topoisomerase II alpha protein fragment (aa1300-1500) was used as the immunogen for the recombinant TOP2A antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the recombinant TOP2A antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the recombinant TOP2A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur Topoisomerase II alpha

Antigène: Topoisomerase II alpha (TOP2A) (Topoisomerase (DNA) II alpha 170kDa (TOP2A))

Autre désignation: TOP2A

Sujet: It recognizes a 170 kDa protein, which is identified as topoisomerase IIAlpha. It shows no cross-reaction with Topoisomerase II beta or I. Topo II Alpha plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells. Topo II Alpha is also implicated in drug resistance of tumor cells and has been shown to be over-expressed in many human cancers. Decreased expression of Topo IIa is the predominant mechanism of resistance to several chemotherapeutic agents.

UniProt: P11388

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases