HAS2 anticorps (AA 138-166)

N° du produit ABIN7870582

Cet anticorps anti-HAS2 Polyclonal Lapin (ABIN7870582) détecte spécifiquement HAS2 dans WB, FACS et IHC (p). L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour HAS2 anticorps (AA 138-166) (ABIN7870582)

Antigène: HAS2 (Hyaluronan Synthase 2 (HAS2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HAS2 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-HAS2 anticorps

Épitope: AA 138-166

Fonction: Hyaluronan synthase 2 Antibody / HAS2

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 138-166 from the human protein was used as the immunogen for the Hyaluronan synthase 2 antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting points. Titration of the Hyaluronan synthase 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Hyaluronan synthase 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur HAS2

Antigène: HAS2 (Hyaluronan Synthase 2 (HAS2))

Autre désignation: Hyaluronan synthase 2

Sujet: Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.

UniProt: Q92819

Pathways: Glycosaminoglycan Metabolic Process