OTUD5 anticorps (AA 167-544)

N° du produit ABIN7871195

Cet anticorps Lapin Polyclonal détecte spécifiquement OTUD5 dans WB. Il présente une réactivité avec des échantillons de Poisson zèbre (Danio rerio).

Aperçu rapide pour OTUD5 anticorps (AA 167-544) (ABIN7871195)

Antigène: OTUD5 (OTU Domain Containing 5 (OTUD5))

Reactivité: Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OTUD5 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-OTUD5 anticorps

Épitope: AA 167-544

Fonction: Zebrafish Otud5 Antibody / Otud5a / Otud5b

Purification: Antigen affinity chromatography

Immunogène: E. coli-derived zebrafish Otud5 recombinant protein (amino acids E167-D544) was used as the immunogen for the Zebrafish Otud5 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal dilution of the Zebrafish Otud5 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the Zebrafish Otud5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur OTUD5

Antigène: OTUD5 (OTU Domain Containing 5 (OTUD5))

Autre désignation: Otud5

Sujet: Otud5, or ovarian tumor domain containing protein five, is a deubiquitinating enzyme that regulates protein stability and cellular signaling by removing ubiquitin chains from target proteins. It is a member of the ovarian tumor domain protease family and plays an important role in controlling immune responses, chromatin structure, and transcriptional regulation.

In zebrafish, Otud5 is expressed during early development and in various adult tissues, particularly in the nervous system, immune-related organs, and proliferative tissues. The zebrafish Otud5 protein is an ortholog of the human OTUD5 gene. Both proteins share conserved catalytic domains and regulatory motifs that are essential for deubiquitinase activity and interaction with signaling complexes.

Functionally, Otud5 acts as a negative regulator of immune signaling by deubiquitinating and stabilizing key proteins in pathways such as type one interferon and nuclear factor kappa B signaling. It also influences chromatin accessibility and transcription by regulating histone modifiers and chromatin remodelers. In humans, mutations in OTUD5 have been linked to developmental disorders involving intellectual disability and immune dysfunction.

In zebrafish, disruption of Otud5 function affects normal embryonic patterning and tissue development, suggesting a conserved role in regulating gene expression and cellular responses during growth and differentiation. Due to this conservation, zebrafish Otud5 is an important tool for modeling human disease mechanisms and studying deubiquitination in vertebrate development and immunity.

UniProt: Q08BW0