MASP1 anticorps (AA 169-580)

N° du produit ABIN7871206

Cet anticorps anti-MASP1 Polyclonal Lapin (ABIN7871206) détecte spécifiquement MASP1 dans WB, ELISA et FACS. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour MASP1 anticorps (AA 169-580) (ABIN7871206)

Antigène: MASP1 (Mannan-Binding Lectin Serine Peptidase 1 (MASP1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MASP1 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Détail du produit anti-MASP1 anticorps

Épitope: AA 169-580

Fonction: MASP1 Antibody / Mannan-binding lectin serine protease 1

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human MASP1 recombinant protein (Position: R169-E580) was used as the immunogen for the MASP1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the MASP1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the MASP1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur MASP1

Antigène: MASP1 (Mannan-Binding Lectin Serine Peptidase 1 (MASP1))

Autre désignation: MASP1

Sujet: MASP1 antibody detects Mannan-binding lectin serine protease 1, encoded by the MASP1 gene on chromosome 3q27.3. MASP1 antibody is commonly used in research on innate immunity, complement activation, and infection biology. MASP1 is a serine protease that associates with mannan-binding lectin (MBL) and ficolins in the lectin pathway of the complement system. It initiates proteolytic cascades leading to opsonization, inflammation, and pathogen clearance. MASP1 is expressed in the liver and circulates in plasma as part of MBL-associated complexes.

Structurally, MASP1 is a ~110 kDa protein composed of CUB domains, EGF-like domains, complement control protein (CCP) repeats, and a C-terminal serine protease domain. Alternative splicing produces multiple isoforms, including MASP1 and MASP3, with distinct activities. These isoforms diversify complement activation roles and are essential for fine-tuning immune responses.

Functionally, MASP1 cleaves complement components C4 and C2, generating C3 convertase in the lectin pathway. It also activates coagulation factors, linking complement with clotting. MASP1 participates in host defense by enhancing pathogen recognition and clearance. Beyond immunity, MASP1 influences angiogenesis and tissue repair. Researchers use MASP1 antibody to study complement activation, innate defense, and coagulation biology.

Clinically, MASP1 variants are associated with susceptibility to infections and inflammatory diseases. Deficiency impairs lectin pathway activation, increasing risk of bacterial and viral infections. Conversely, overactivation of MASP1 contributes to autoimmune diseases, sepsis, and ischemia-reperfusion injury. Mutations in MASP1 are linked to 3MC syndrome, a developmental disorder with craniofacial anomalies and growth defects. As complement therapeutics are developed, MASP1 is an emerging target for intervention. NSJ Bioreagents provides MASP1 antibody for complement biology, infectious disease, and immunology research.

Experimentally, MASP1 antibody is applied in western blotting to detect the ~110 kDa protein, in ELISA to measure plasma levels, and in immunohistochemistry to examine tissue expression. Co-immunoprecipitation with MASP1 antibody identifies binding partners within MBL-associated complexes.

UniProt: P48740

Pathways: Système du Complément