Recombinant Dystrophin anticorps (AA 1700-2300)

N° du produit ABIN7871256

L’anticorps anti-Dystrophin Monoclonal Lapin est utilisé pour la détection de Dystrophin dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour Recombinant Dystrophin anticorps (AA 1700-2300) (ABIN7871256)

Antigène: Dystrophin (DMD)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Dystrophin est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: DMD-8773R

Détail du produit anti-Dystrophin anticorps

Épitope: AA 1700-2300

Fonction: Dystrophin Antibody / DMD

Purification: Protein A/G affinity

Immunogène: A recombinant partial protein sequence (within amino acids 1700-2300) from the human protein was used as the immunogen for the Dystrophin antibody.

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal dilution of the Dystrophin antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Dystrophin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur Dystrophin

Antigène: Dystrophin (DMD)

Autre désignation: Dystrophin

Sujet: Dystrophin-glycoprotein complex (DGC) connects the F-Actin cytoskeleton on the inner surface of muscle fibers to the surrounding extracellular matrix, through the cell membrane interface. A deficiency in this protein contributes to Duchenne (DMD) and Becker (BMD) muscular dystrophies. The human dystrophin gene measures 2.4 megabases, has more than 80 exons, produces a 14 kb mRNA and contains at least 8 independent tissue-specific promoters and 2 poly A sites. The dystrophin mRNA can undergo differential splicing and produce a range of transcripts that encode a large set of proteins. Dystrophin represents approximately 0.002 % of total striated muscle protein and localizes to triadic junctions in skeletal muscle, where it is thought to influence calcium ion homeostasis and force transmission.

UniProt: P11532

Pathways: Skeletal Muscle Fiber Development