MUC4 anticorps (AA 1730-1864)

N° du produit ABIN7871280

L’anticorps anti-MUC4 Monoclonal Souris est utilisé pour la détection de MUC4 dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour MUC4 anticorps (AA 1730-1864) (ABIN7871280)

Antigène: MUC4 (Mucin 4, Cell Surface Associated (MUC4))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MUC4 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: MUC4-3105

Détail du produit anti-MUC4 anticorps

Épitope: AA 1730-1864

Fonction: MUC4 Antibody / Mucin-4

Purification: Protein G affinity chromatography

Immunogène: Amino acids 1730-1864 from the human protein were used as the immunogen for this MUC4 antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the MUC4 antibody to be titered up or down for optimal performance.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the MUC4 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur MUC4

Antigène: MUC4 (Mucin 4, Cell Surface Associated (MUC4))

Autre désignation: MUC4

Sujet: The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. MUC-4 transcripts have been detected in normal respiratory epithelium and lung. MUC-4 is a very specific (100 % ) and sensitive (90 %) marker of lung adenocarcinomas and is negative for mesotheliomas. Reportedly, MUC-4 expression in invasive ductal carcinoma of the pancreas is an independent factor for poor prognosis.

UniProt: Q99102

Pathways: Regulation of Leukocyte Mediated Immunity