NPM1 anticorps (AA 185-287)

N° du produit ABIN7871494

Cet anticorps anti-NPM1 Monoclonal Souris (Clone NLPP1-1) (ABIN7871494) détecte spécifiquement NPM1 dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour NPM1 anticorps (AA 185-287) (ABIN7871494)

Antigène: NPM1 (Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NPM1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: NLPP1-1

Détail du produit anti-NPM1 anticorps

Épitope: AA 185-287

Fonction: NPM Antibody / Nucleophosmin

Purification: Protein G affinity chromatography

Immunogène: A portion of amino acids 185-287 from the human protein was used as the immunogen for the NPM antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the NPM antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide, *For IHC use only*

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the NPM antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur NPM1

Antigène: NPM1 (Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1))

Autre désignation: NPM

Sujet: The protein encoded by the NPM1 gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. [RefSeq]

UniProt: P06748

Pathways: Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly