Fibromodulin anticorps (AA 19-376)

N° du produit ABIN7871589

L’anticorps anti-Fibromodulin Polyclonal Lapin est utilisé pour la détection de Fibromodulin dans des échantillons de Humain et Souris. Il a été validé pour WB, ELISA et FACS.

Aperçu rapide pour Fibromodulin anticorps (AA 19-376) (ABIN7871589)

Antigène: Fibromodulin (FMOD)

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Fibromodulin est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Détail du produit anti-Fibromodulin anticorps

Épitope: AA 19-376

Fonction: FMOD Antibody / Fibromodulin

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human Fibromodulin/FMOD recombinant protein (Position: Q19-I376) was used as the immunogen for the FMOD antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the FMOD antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the FMOD antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur Fibromodulin

Antigène: Fibromodulin (FMOD)

Autre désignation: FMOD

Sujet: FMOD antibody detects Fibromodulin, encoded by the FMOD gene. Fibromodulin is a small leucine-rich repeat proteoglycan of the extracellular matrix that regulates collagen fibrillogenesis and tissue organization. FMOD antibody provides researchers with a specific reagent to study extracellular matrix biology, connective tissue remodeling, and disease processes involving abnormal matrix composition.

Fibromodulin is secreted by fibroblasts and chondrocytes and associates with collagen fibrils. Research using FMOD antibody has shown that it binds to type I and type II collagen fibrils, regulating their diameter and spacing. This interaction ensures proper biomechanical properties of tissues such as cartilage, tendons, and skin. Without Fibromodulin, collagen fibrils are irregular in size and arrangement, leading to impaired tissue strength and function.

Studies with FMOD antibody have revealed roles in tissue repair and wound healing. Fibromodulin is upregulated following injury and promotes scar formation by modulating collagen deposition and organization. It also influences the recruitment of macrophages and fibroblasts, linking extracellular matrix remodeling with immune responses. These findings highlight the importance of Fibromodulin in regenerative biology.

Fibromodulin is also involved in angiogenesis. Research using FMOD antibody has demonstrated that it binds to growth factors and modulates endothelial cell function. By interacting with transforming growth factor beta and vascular endothelial growth factor pathways, Fibromodulin regulates angiogenic responses during development and repair. Dysregulation can contribute to impaired healing or pathological angiogenesis in tumors.

Disease studies have connected Fibromodulin with osteoarthritis, fibrosis, and cancer. Research using FMOD antibody has shown that altered Fibromodulin expression affects cartilage integrity and progression of degenerative joint disease. Elevated expression has been associated with fibrotic disorders, while aberrant expression in tumors may contribute to cancer progression by modifying extracellular matrix stiffness and promoting invasion.

FMOD antibody is widely applied in immunohistochemistry, western blotting, and immunofluorescence. Immunohistochemistry identifies expression in connective tissues, western blotting quantifies protein levels and isoforms, and immunofluorescence reveals localization within matrix-rich environments. These methods make FMOD antibody valuable in extracellular matrix research.

By supplying validated FMOD antibody reagents, NSJ Bioreagents supports studies into collagen biology, tissue repair, and disease. Detection of Fibromodulin provides insight into how small leucine-rich proteoglycans regulate extracellular matrix function and pathology.

UniProt: Q06828

Pathways: Glycosaminoglycan Metabolic Process