SUV420H2/KMT5C anticorps (AA 195-220)

N° du produit ABIN7871703

L’anticorps anti-SUV420H2/KMT5C Polyclonal Lapin est utilisé pour la détection de SUV420H2/KMT5C dans des échantillons de Souris et Humain. Il a été validé pour WB et FACS.

Aperçu rapide pour SUV420H2/KMT5C anticorps (AA 195-220) (ABIN7871703)

Antigène: SUV420H2/KMT5C (SUV420H2) (Suppressor of Variegation 4-20 Homolog 2 (SUV420H2))

Reactivité: Souris, Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SUV420H2/KMT5C est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Détail du produit anti-SUV420H2/KMT5C anticorps

Épitope: AA 195-220

Fonction: KMT5C Antibody / SUV420H2

Immunogène: A portion of amino acids 195-220 from the human protein was used as the immunogen for the KMT5C antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: The stated application concentrations are suggested starting points. Titration of the KMT5C antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Aliquot the KMT5C antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur SUV420H2/KMT5C

Antigène: SUV420H2/KMT5C (SUV420H2) (Suppressor of Variegation 4-20 Homolog 2 (SUV420H2))

Autre désignation: KMT5C

Sujet: KMT5C, also called Suppressor of variegation 4-20 homolog 2, Su(var)4-20 homolog 2 and Suv4-20h2, belongs to a family of proteins called lysine methyltransferases, which are enzymes that play a key role in the modification of histone proteins. Histones are proteins that help package and organize DNA in the nucleus of a cell, and modifications to these proteins can have profound effects on gene expression. Studies have shown that KMT5C specifically targets histone H4 lysine 20 (H4K20) for methylation, which has been linked to the regulation of gene transcription and DNA replication. Dysregulation of this process has been implicated in various diseases, including cancer and developmental disorders. In cancer, aberrant expression of KMT5C has been observed in several tumor types, and its overexpression has been associated with poor prognosis. Mutations in the KMT5C gene have been linked to developmental disorders, such as intellectual disability and autism spectrum disorders. These findings highlight the importance of KMT5C in brain development and function, and provide new insights into the underlying mechanisms of these conditions.

UniProt: Q86Y97