HSD17B1 anticorps (AA 20-249)

N° du produit ABIN7871848

Cet anticorps anti-HSD17B1 Polyclonal Lapin (ABIN7871848) détecte spécifiquement HSD17B1 dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour HSD17B1 anticorps (AA 20-249) (ABIN7871848)

Antigène: HSD17B1 (Hydroxysteroid (17-Beta) Dehydrogenase 1 (HSD17B1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HSD17B1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-HSD17B1 anticorps

Épitope: AA 20-249

Fonction: HSD17B1 Antibody

Purification: Antigen affinity purified

Immunogène: Amino acids A20-K249 from the human protein were used as the immunogen for the HSD17B1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the HSD17B1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the HSD17B1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur HSD17B1

Antigène: HSD17B1 (Hydroxysteroid (17-Beta) Dehydrogenase 1 (HSD17B1))

Autre désignation: HSD17B1

Sujet: Estradiol 17-beta-dehydrogenase 1 is an enzyme that in humans is encoded by the HSD17B1 gene. This gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The encoded protein catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. This gene is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Polymorphisms in this gene have been linked to breast and prostate cancer. A pseudogene of this gene has been identified. Alternative splicing results in multiple transcript variants.

UniProt: P14061

Pathways: Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis