TCF7 anticorps (AA 200-400)

N° du produit ABIN7872062

Cet anticorps Souris Monoclonal détecte spécifiquement TCF7 dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour TCF7 anticorps (AA 200-400) (ABIN7872062)

Antigène: TCF7 (Transcription Factor 7 (T-Cell Specific, HMG-Box) (TCF7))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TCF7 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: TCF7-7631

Détail du produit anti-TCF7 anticorps

Épitope: AA 200-400

Fonction: TCF7 Antibody / Transcription Factor 7 (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: A recombinant partial protein sequence (within amino acids 200-400) from the human protein was used as the immunogen for the TCF7 antibody.

Isotype: IgG2, kappa

Information d'application

Indications d'application: Optimal dilution of the TCF7 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the TCF7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur TCF7

Antigène: TCF7 (Transcription Factor 7 (T-Cell Specific, HMG-Box) (TCF7))

Autre désignation: TCF7

Sujet: Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages (By similarity). Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes.

UniProt: P36402

Pathways: Signalisation WNT