TCF7 anticorps (AA 200-400)

N° du produit ABIN7872063

L’anticorps anti-TCF7 Monoclonal Souris est utilisé pour la détection de TCF7 dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour TCF7 anticorps (AA 200-400) (ABIN7872063)

Antigène: TCF7 (Transcription Factor 7 (T-Cell Specific, HMG-Box) (TCF7))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TCF7 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: TCF7-7631

Détail du produit anti-TCF7 anticorps

Épitope: AA 200-400

Fonction: TCF7 Antibody / Transcription Factor 7

Purification: Protein A/G affinity

Immunogène: A recombinant partial protein sequence (within amino acids 200-400) from the human protein was used as the immunogen for the TCF7 antibody.

Isotype: IgG2, kappa

Information d'application

Indications d'application: Optimal dilution of the TCF7 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the TCF7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur TCF7

Antigène: TCF7 (Transcription Factor 7 (T-Cell Specific, HMG-Box) (TCF7))

Autre désignation: TCF7

Sujet: Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages (By similarity). Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes.

UniProt: P36402

Pathways: Signalisation WNT