TARDBP anticorps (AA 200-414)

N° du produit ABIN7872068

Cet anticorps Souris Monoclonal détecte spécifiquement TARDBP dans WB, ELISA et IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour TARDBP anticorps (AA 200-414) (ABIN7872068)

Antigène: TARDBP (TAR DNA Binding Protein (TARDBP))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TARDBP est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: TARDP-349

Détail du produit anti-TARDBP anticorps

Épitope: AA 200-414

Fonction: TARDBP Antibody / TAR DNA binding protein / TDP43

Purification: Protein A/G affinity

Immunogène: A recombinant fragment from the human protein (within amino acids 200-414) was used as the immunogen for the TARDBP antibody.

Isotype: IgG1

Information d'application

Indications d'application: Optimal dilution of the TARDBP antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the TARDBP antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur TARDBP

Antigène: TARDBP (TAR DNA Binding Protein (TARDBP))

Autre désignation: TARDBP

Sujet: TARDBP (TAR DNA binding protein), also known as TDP-43, is a nuclear protein that contains two RRM (RNA recognition motif) domains. Ubiquitously expressed with highest levels found in placenta, lung, pancreas, spleen and genital tract, TARDBP functions as a DNA-binding protein and specifically binds to the TAR DNA sequence motifs of HIV. Via this association with TAR motifs, TARDBP acts as a transcriptional repressor and inhibits HIV-1 transcription. TARDBP can also function as a negative regulator of splicing activity and is known to be involved in the splicing of CFTR (cystic fibrosis transmembrane receptor). In addition, TARDBP is a major component of ubiquitin-positive inclusion bodies that are prominent in many neurodegenerative diseases. This suggests that TARDBP may play a role in the development of neurodegenerative disorders. Due to alternative splicing events, various isoforms exist for TARDBP.

UniProt: Q13148

Pathways: Positive Regulation of Peptide Hormone Secretion