C6orf150 anticorps (AA 208-522)

N° du produit ABIN7872110

Cet anticorps Lapin Polyclonal détecte spécifiquement C6orf150 dans WB, ELISA, FACS et IF. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour C6orf150 anticorps (AA 208-522) (ABIN7872110)

Antigène: C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp C6orf150 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF)

Détail du produit anti-C6orf150 anticorps

Épitope: AA 208-522

Fonction: cGAS Antibody / cGAMP Synthase

Purification: Antigen affinity purified

Immunogène: Recombinant human protein (amino acids L208-F522) was used as the immunogen for the cGAS antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the cGAS antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the cGAS antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur C6orf150

Antigène: C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))

Autre désignation: cGAS

Sujet: CGAS (cyclic GMP-AMP synthase), also known as MB21D1 (Mab-21 domain containing 1), h-cGAS or C6orf150, is a 522 amino acid cytoplasmic nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. cGAS is suggested to have antiviral activity by acting as a key cytosolic DNA sensor. cGAS binds to cytosolic DNA, which leads to cGAMP synthesis and activation of TMEM173, thereby trigger type-I interferon production. Expressed in monocytic cell line THP1, cGAS exists as two alternatively spliced isoforms and is encoded by a gene located on human chromosome 6q13.

UniProt: Q8N884

Pathways: Activation of Innate immune Response