Geminin anticorps (AA 21-196)

N° du produit ABIN7872144

L’anticorps anti-Geminin Polyclonal Lapin est utilisé pour la détection de Geminin dans des échantillons de Humain et Souris. Il a été validé pour WB, IF, ELISA, IHC (p) et FACS.

Aperçu rapide pour Geminin anticorps (AA 21-196) (ABIN7872144)

Antigène: Geminin (GMNN) (Geminin, DNA Replication Inhibitor (GMNN))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Geminin est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Détail du produit anti-Geminin anticorps

Épitope: AA 21-196

Fonction: Geminin Antibody / GMNN

Purification: Affinity purified

Immunogène: An E. coli-derived human protein (amino acids V21-E196) was used as the immunogen for the Geminin antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the Geminin antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the Geminin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur Geminin

Antigène: Geminin (GMNN) (Geminin, DNA Replication Inhibitor (GMNN))

Autre désignation: Geminin

Sujet: Geminin, DNA replication inhibitor, also known as GMNN, is a protein in humans encoded by the GMNN gene. This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16.

UniProt: O75496

Pathways: EGFR Signaling Pathway, DNA Replication