CHGB anticorps (AA 250-450)

N° du produit ABIN7872902

Cet anticorps Souris Monoclonal détecte spécifiquement CHGB dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour CHGB anticorps (AA 250-450) (ABIN7872902)

Antigène: CHGB (Chromogranin B (Secretogranin 1) (CHGB))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CHGB est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CHGB-7756

Détail du produit anti-CHGB anticorps

Épitope: AA 250-450

Fonction: Chromogranin B Antibody / CHGB / Secretogranin I

Purification: Protein A/G affinity

Immunogène: A recombinant partial protein sequence (within amino acids 250-450) from the human protein was used as the immunogen for the Chromogranin B antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the Chromogranin B antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Chromogranin B antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur CHGB

Antigène: CHGB (Chromogranin B (Secretogranin 1) (CHGB))

Autre désignation: Chromogranin B

Sujet: Chromogranins (secretogranins) are acidic glycoproteins that localize within secretory granules of endocrine, neuroendocrine and neuronal tissue. Family members include chromogranin A (Chr-A), chromogranin B (Chr-B, also known as secretogranin I) chromogranin C (also known as secretogranin II or Sg II), secretogranin III (Sg III or SCG3). High levels of Chr-A expression is a characteristic of neuroendocrine tumors. Pancreastatin is a peptide derived from Chr-A which inhibits Insulin secretion, exocrine pancreatic secretion and gastric acid secretion. Pancreastatin exists as two forms, the major form is expressed in stomach and colon extracts. In neuroendocrine cells the level Sg II has been shown to increase four-fold in response to histamine, while levels of Chr-A and Chr-B showed little or no increase. Sg III is an acidic secretory protein expressed in neuronal and endocrine cells. In the anterior lobe of the rat pituitary gland, Sg III is present in mammotropes and thyrotropes, moderately in gonadotropes and corticotropes, though not in somatotropes. Sg III and carboxypeptidase E (CPE) bind specifically to cholesterol-rich secretory granule (SG) membranes.

UniProt: P05060