SEPN1 anticorps (AA 260-590)

N° du produit ABIN7873028

Cet anticorps Lapin Polyclonal détecte spécifiquement SEPN1 dans WB, ELISA et FACS. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour SEPN1 anticorps (AA 260-590) (ABIN7873028)

Antigène: SEPN1 (Selenoprotein N, 1 (SEPN1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SEPN1 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Détail du produit anti-SEPN1 anticorps

Épitope: AA 260-590

Fonction: SEPN1 Antibody / Selenoprotein N / SELENON / SELN

Purification: Antigen affinity purified

Immunogène: E. coli-derived recombinant human protein (amino acids H260-P590) was used as the immunogen for the SEPN1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the SEPN1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the SEPN1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur SEPN1

Antigène: SEPN1 (Selenoprotein N, 1 (SEPN1))

Autre désignation: SEPN1

Sujet: This gene encodes a glycoprotein that is localized in the endoplasmic reticulum. It plays an important role in cell protection against oxidative stress, and in the regulation of redox-related calcium homeostasis. Mutations in this gene are associated with early onset muscle disorders, referred to as SEPN1-related myopathy. SEPN1-related myopathy consists of 4 autosomal recessive disorders, originally thought to be separate entities: rigid spine muscular dystrophy (RSMD1), the classical form of multiminicore disease, desmin related myopathy with Mallory-body like inclusions, and congenital fiber-type disproportion (CFTD). This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A second stop-codon redefinition element (SRE) adjacent to the UGA codon has been identified in this gene (PMID:15791204). SRE is a phylogenetically conserved stem-loop structure that stimulates readthrough at the UGA codon, and augments the Sec insertion efficiency by SECIS. Alternatively spliced transcript variants have been found for this gene.

UniProt: Q9NZV5

Pathways: Skeletal Muscle Fiber Development