PLAGL2 anticorps (AA 269-365)

N° du produit ABIN7873070

Cet anticorps Lapin Polyclonal détecte spécifiquement PLAGL2 dans ELISA et WB. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour PLAGL2 anticorps (AA 269-365) (ABIN7873070)

Antigène: PLAGL2 (Pleiomorphic Adenoma Gene-Like 2 (PLAGL2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PLAGL2 est non-conjugé

Application: ELISA, Western Blotting (WB)

Détail du produit anti-PLAGL2 anticorps

Épitope: AA 269-365

Fonction: PLAGL2 Antibody / Pleiomorphic adenoma gene-like 2

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human PLAGL2 recombinant protein (Position: K269-E365) was used as the immunogen for the PLAGL2 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the PLAGL2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the PLAGL2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur PLAGL2

Antigène: PLAGL2 (Pleiomorphic Adenoma Gene-Like 2 (PLAGL2))

Autre désignation: PLAGL2

Sujet: PLAGL2 antibody detects Pleiomorphic adenoma gene-like protein 2, a zinc finger transcription factor involved in cell proliferation, differentiation, and tumorigenesis. Encoded by the PLAGL2 gene on chromosome 20q11.21, this nuclear protein belongs to the PLAG family of transcription factors, which regulate gene expression through DNA binding to consensus sequences within promoter regions. PLAGL2 is known for its dual role in promoting stem cell maintenance and activating oncogenic pathways, as well as influencing differentiation and apoptosis depending on cellular context.

Structurally, PLAGL2 contains seven C2H2-type zinc finger domains that enable DNA binding and transcriptional activation of target genes such as IGF2, PAI-1, and NRP1. It interacts with coactivators and chromatin remodeling proteins to modulate gene transcription linked to growth and migration. PLAGL2 contributes to the regulation of Wnt and hypoxia signaling pathways by activating genes involved in angiogenesis and metabolic adaptation.

The PLAGL2 antibody is widely used in cancer biology, developmental biology, and transcriptional regulation research to study gene activation and oncogenic signaling. Western blot analysis typically identifies a 57 kilodalton band corresponding to PLAGL2, while immunofluorescence shows nuclear localization consistent with its role as a transcriptional regulator. This antibody allows investigation of transcriptional networks and regulatory mechanisms controlling cellular transformation and differentiation.

In oncology, PLAGL2 has been implicated in colorectal, lung, and brain cancers where it promotes stem-like characteristics, epithelial-mesenchymal transition, and resistance to apoptosis. Conversely, in certain developmental contexts, PLAGL2 supports normal differentiation by activating lineage-specific genes. The PLAGL2 antibody provides a powerful tool for exploring these complex regulatory roles in tumor and stem cell biology. NSJ Bioreagents validates this antibody for its applications, ensuring dependable detection in transcriptional and cancer signaling studies.

UniProt: Q9UPG8