PDCD1LG2 anticorps (AA 27-220)

N° du produit ABIN7873097

Cet anticorps Souris Monoclonal détecte spécifiquement PDCD1LG2 dans FACS. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour PDCD1LG2 anticorps (AA 27-220) (ABIN7873097)

Antigène: PDCD1LG2 (Programmed Cell Death 1 Ligand 2 (PDCD1LG2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PDCD1LG2 est non-conjugé

Application: Flow Cytometry (FACS)

Clone: PDL2-1850

Détail du produit anti-PDCD1LG2 anticorps

Épitope: AA 27-220

Fonction: PDL2 Antibody / Programmed death ligand 2 / CD273

Purification: Protein G affinity chromatography

Immunogène: A recombinant fragment of human PD-L2 protein within amino acids 27-220 was used as the immunogen for the PDL2 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the PDL2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the PDL2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur PDCD1LG2

Antigène: PDCD1LG2 (Programmed Cell Death 1 Ligand 2 (PDCD1LG2))

Autre désignation: PDL2

Sujet: Recognizes a protein of about 31 kDa, which is identified as PD-L2 (same as PDCD1LG2). Engagement of CD28 by B7-1 (CD80) or B7-2 (CD86) in the presence of antigen promotes T cell proliferation, cytokine production, differentiation of effector T cells and the induction of Bcl-x, a promoter of T cell survival. Conversely, engagement of CTLA4 by B7-1 or B7-2 may inhibit proliferation and IL-2 production. PD-L2 does not bind CD28, cytotoxic T lymphocyte A4 or ICOS (inducible co-stimulator). The constitutive expression of PD-L1 and PD-L2 on parenchymal cells of heart, lung and kidney suggests that the Pdcd-1-Pdcd-L system could provide unique negative signaling to help prevent autoimmune disease.