BDNF anticorps (AA 27-278)

N° du produit ABIN7873108

Cet anticorps anti-BDNF Polyclonal Lapin (ABIN7873108) détecte spécifiquement BDNF dans WB et IHC (p). L’anticorps est réactif avec des échantillons de Poisson zèbre (Danio rerio).

Aperçu rapide pour BDNF anticorps (AA 27-278) (ABIN7873108)

Antigène: BDNF (Brain-Derived Neurotrophic Factor (BDNF))

Reactivité: Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BDNF est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-BDNF anticorps

Épitope: AA 27-278

Fonction: Zebrafish Bdnf Antibody / Brain-derived neurotrophic factor

Purification: Antigen affinity chromatography

Immunogène: E. coli-derived zebrafish Bdnf recombinant protein (amino acids A27-R278) was used as the immunogen for the Zebrafish Bdnf antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal dilution of the Zebrafish Bdnf antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the Zebrafish Bdnf antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur BDNF

Antigène: BDNF (Brain-Derived Neurotrophic Factor (BDNF))

Autre désignation: Bdnf

Sujet: Brain-derived neurotrophic factor (Bdnf) is a key member of the neurotrophin family, which plays a vital role in the development, maintenance, and plasticity of the nervous system. In zebrafish (Danio rerio), the bdnf gene encodes a protein highly conserved with its mammalian counterpart, sharing significant sequence and functional homology. Bdnf is critically involved in promoting the survival and differentiation of neurons, synaptic plasticity, and modulation of neurogenesis during development and in the adult brain.

Expression of Bdnf in zebrafish is observed early in embryogenesis and persists in various regions of the central nervous system, including the forebrain, optic tectum, and spinal cord. Zebrafish Bdnf interacts primarily with the high-affinity receptor TrkB (Ntrk2), activating intracellular signaling pathways such as PI3K-Akt, MAPK/ERK, and PLC-i³, which are essential for neurotrophic support and synaptic function.

Due to the genetic tractability and optical transparency of zebrafish embryos, this model organism is widely used to investigate Bdnf-mediated neuronal development, behavior, and regeneration. Studies have also linked altered bdnf expression to stress responses, learning, and memory in zebrafish, highlighting its relevance in neurodevelopmental and neuropsychiatric research.

Pathways: Signalisation RTK, Synaptic Membrane, Feeding Behaviour, Dicarboxylic Acid Transport, Regulation of long-term Neuronal Synaptic Plasticity