Recombinant IDH1 anticorps (AA 281-414)

N° du produit ABIN7873287

L’anticorps anti-IDH1 Monoclonal Lapin est utilisé pour la détection de IDH1 dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour Recombinant IDH1 anticorps (AA 281-414) (ABIN7873287)

Antigène: IDH1 (Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp IDH1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: IDH1-6806R

Détail du produit anti-IDH1 anticorps

Épitope: AA 281-414

Fonction: IDH1 Antibody / Isocitrate Dehydrogenase (R132H mutant)

Purification: Protein A/G affinity

Immunogène: A portion of amino acids 281-414 was used as the immunogen for the IDH1 R132H antibody.

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal dilution of the IDH1 R132H antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the IDH1 R132H antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur IDH1

Antigène: IDH1 (Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1))

Autre désignation: IDH1

Sujet: IDH1 R132H antibody binds to IDH1-mutated protein, but does not bind the wild-type IDH1 protein. IDH1 R132H point mutations are frequently seen in World Health Organization grade II and III gliomas and are believed to constitute an early step in tumorigenesis. IDH1 R132H can be used as a diagnostic marker to help differentiate infiltrating gliomas from gliosis, and as a prognostic marker for gliomas and secondary glioblastoma multiforme. IDH1 R132H antibody shows strong cytoplasmic staining and weaker nuclear staining in tumor cells with the R132H-mutated peptide. Diffuse staining of the fibrillary tumor matrix is also seen.

UniProt: O75874

Pathways: L'effet Warburg