Integrin beta 4 anticorps (AA 29-431)

N° du produit ABIN7873421

Cet anticorps Souris Monoclonal détecte spécifiquement Integrin beta 4 dans WB, FACS et IF. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Integrin beta 4 anticorps (AA 29-431) (ABIN7873421)

Antigène: Integrin beta 4 (ITGB4)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Integrin beta 4 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: 7G10D2

Détail du produit anti-Integrin beta 4 anticorps

Épitope: AA 29-431

Fonction: Integrin beta 4 Antibody / ITGB4 / CD104

Purification: Antigen affinity purified

Immunogène: Recombinant human protein (amino acids R29-K431) was used as the immunogen for the Integrin beta 4 antibody.

Isotype: IgG2b

Information d'application

Indications d'application: Optimal dilution of the Integrin beta 4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the Integrin beta 4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur Integrin beta 4

Antigène: Integrin beta 4 (ITGB4)

Autre désignation: Integrin beta 4

Sujet: ITGB4 (Integrin, beta-4), also known as CD104 (Cluster of Differentiation 104), is a human gene. The gene encodes the integrin beta 4 subunits, a receptor for the laminins. This subunit tends to associate with alpha 6 subunits and is likely to play a pivotal role in the biology of invasive carcinoma. The ITGB4 gene is mapped on 17q25.1. Using expression profiling, Yang et al. found that ITGB4 was upregulated 6-fold by ZKSCAN3 in transfected human colon cancer cells compared with parental cells. They confirmed that ZKSCAN3 bound the promoter of ITGB4 in vitro and in vivo. ITGB4 knockdown by short hairpin RNA countered ZKSCAN3-augmented anchorage-independent colony formation in the colon cancer cell lines. The integrin beta-4 subunit is characterized by an unusually long cytoplasmic domain that harbors 4 fibronectin type III (FNIII) repeats, residing in 2 pairs separated by a connecting segment. Vidal et al. found compound heterozygosity for mutations in the ITGB4 gene in an infant with junctional epidermolysis bullosa associated with pyloric atresia.

UniProt: P16144

Pathways: Integrin Complex