SLC38A9 anticorps (AA 33-450)

N° du produit ABIN7874002

Cet anticorps anti-SLC38A9 Polyclonal Lapin (ABIN7874002) détecte spécifiquement SLC38A9 dans ELISA, WB, IF et FACS. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour SLC38A9 anticorps (AA 33-450) (ABIN7874002)

Antigène: SLC38A9 (Solute Carrier Family 38, Member 9 (SLC38A9))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SLC38A9 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Détail du produit anti-SLC38A9 anticorps

Épitope: AA 33-450

Fonction: SLC38A9 Antibody / URLC11

Purification: Antigen affinity purified

Immunogène: An E.coli-derived human recombinant protein (amino acids D33-Q450) was used as the immunogen for the SLC38A9 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the SLC38A9 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the SLC38A9 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur SLC38A9

Antigène: SLC38A9 (Solute Carrier Family 38, Member 9 (SLC38A9))

Autre désignation: SLC38A9

Sujet: Solute carrier family 38 member 9 is a protein that in humans is encoded by the SLC38A9 gene. Sodium-coupled neutral amino acid transporter 9 (SLC38A9) is a lysosomal amino acid transporter, involved in the regulation of mechanistic target of rapamycin complex 1 (mTORC1) activity in response to amino acid levels within the lysosomal lumen. A sodium-couple amino acid transporter at the lysosome, SLC38A9, senses arginine from within the lysosome to convey arginine sufficiency to mTORC1. SLC38A9 forms a complex with other lysosomal resident proteins including the v-ATPase and a pentameric complex called Ragulator. v-ATPase function is necessary for mTORC1 activation, but the molecular mechanism of this regulation is currently unclear2. Ragulator binds strongly to the Rag GTPases and was shown to function as a guanine exchange factor (GEF) for RagA/B. Potentially SLC38A9 and the v-ATPase are able to regulate mTORC1 activity by modulating Ragulatori 1/2s GEF activity. RagA/B is not the only Rag GTPase that is regulated, but a Folliculin-FNIP2 complex is a GAP for RagC/D. In short, SLC38A9 is a functional component of the lysosomal amino acid sensing machinery involved in the control of mTORC1 activity, that underlies the regulation of the metabolic status and cellular responses to growth factors, energy, glucose and amino acid levels.

UniProt: Q8NBW4