DDR1 anticorps (AA 341-909)

N° du produit ABIN7874100

L’anticorps anti-DDR1 Polyclonal Lapin est utilisé pour la détection de DDR1 dans des échantillons de Humain, Rat et Souris. Il a été validé pour WB, ELISA, IHC (p), FACS, IF et ICC.

Aperçu rapide pour DDR1 anticorps (AA 341-909) (ABIN7874100)

Antigène: DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DDR1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (IF), Immunocytochemistry (ICC)

Détail du produit anti-DDR1 anticorps

Épitope: AA 341-909

Fonction: DDR1 Antibody

Purification: Affinity purified

Immunogène: A human recombinant protein (amino acids R341-A909) was used as the immunogen for the DDR1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the DDR1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the DDR1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur DDR1

Antigène: DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))

Autre désignation: DDR1

Sujet: DDR1 (Discoidin domain receptor family, member 1) also known as NEP, EDDR1, NTRK4, TRKE, DDR, CAK or RTK6, is a human gene. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. The DDR1 gene is mapped on 6p21.33. The fibrillar collagens and immobilized collagen activated DDR1 receptor phosphorylation after prolonged treatment. Bhatt et al. (2000) showed thatDdr1was highly expressed in the cerebellum of developing and adult mouse brain, and that bothDdr1and collagen IV were highly expressed in the pial layer of the cerebellar cortex cocultures of collagen I- and IV-expressing mouse pial cells withDdr1-expressing granule cells resulted in granule cell neurite extension. Inhibition of collagen-Ddr1signaling reduced granule cell neurite elongation.

UniProt: Q08345

Pathways: Signalisation RTK, Smooth Muscle Cell Migration