MCM4 anticorps (AA 343-659)

N° du produit ABIN7874108

Cet anticorps Lapin Polyclonal détecte spécifiquement MCM4 dans WB. Il présente une réactivité avec des échantillons de Poisson zèbre (Danio rerio).

Aperçu rapide pour MCM4 anticorps (AA 343-659) (ABIN7874108)

Antigène: MCM4 (Minichromosome Maintenance Deficient 4 (MCM4))

Reactivité: Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MCM4 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-MCM4 anticorps

Épitope: AA 343-659

Fonction: Zebrafish Mcm4 Antibody

Purification: Antigen affinity chromatography

Immunogène: An E.coli-derived zebrafish Mcm4 recombinant protein (amino acids M343-I659) was used as the immunogen for the Zebrafish Mcm4 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal dilution of the Zebrafish Mcm4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the Zebrafish Mcm4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur MCM4

Antigène: MCM4 (Minichromosome Maintenance Deficient 4 (MCM4))

Autre désignation: Mcm4

Sujet: Minichromosome maintenance complex component 4 (MCM4) is a core part of the MCM2-7 helicase complex, which is essential for the initiation and elongation phases of eukaryotic DNA replication. The MCM complex functions as the replicative helicase, unwinding double-stranded DNA at replication forks to enable the synthesis of new DNA strands.

In zebrafish (Danio rerio), mcm4 is a highly conserved gene with critical roles during early embryogenesis and cell proliferation. Expression of mcm4 is enriched in rapidly dividing tissues and during periods of intense developmental activity, reflecting its importance in genome stability and cell cycle progression.

Zebrafish models deficient in Mcm4 function have been used to study mechanisms of DNA replication stress, genomic instability, and the cellular response to DNA damage. Additionally, because of its conservation and similarity to human MCM4, zebrafish serves as a useful system for modeling MCM-related human disorders, such as Meier-Gorlin syndrome and cancer predisposition syndromes linked to replication licensing defects.

The zebrafish MCM4 protein is a valuable tool for investigating DNA replication dynamics, cell cycle regulation, and the molecular basis of developmental and proliferative diseases.

UniProt: Q6NZV2

Pathways: Réparation de l'ADN, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA