Fascin anticorps (AA 350-400)

N° du produit ABIN7874183

Cet anticorps Souris Monoclonal détecte spécifiquement Fascin dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Fascin anticorps (AA 350-400) (ABIN7874183)

Antigène: Fascin (FSCN1)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Fascin est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: FSCN1-7207

Détail du produit anti-Fascin anticorps

Épitope: AA 350-400

Fonction: Fascin 1 Antibody / FSCN1 (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: A recombinant partial protein sequence (within amino acids 350-400) from the human protein was used as the immunogen for the Fascin 1 antibody.

Isotype: IgG2a, kappa

Information d'application

Indications d'application: Optimal dilution of the Fascin 1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the Fascin 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur Fascin

Antigène: Fascin (FSCN1)

Autre désignation: Fascin 1

Sujet: Recognizes a protein of 55 kDa, which is identified as fascin-1. Its actin binding ability is regulated by phosphorylation. Antibody to fascin-1 is a very sensitive marker for Reed-Sternberg cells and variants in nodular sclerosis, mixed cellularity, and lymphocyte depletion Hodgkin s disease. It is uniformly negative in lymphoid cells, plasma cells, and myeloid cells. Fascin-1 is also expressed in dendritic cells. This marker may be helpful to distinguish between Hodgkin lymphoma and non-Hodgkin lymphoma in difficult cases. Also, the lack of expression of fascin-1 in the neoplastic follicles in follicular lymphoma may be helpful in distinguishing these lymphomas from reactive follicular hyperplasia in which the number of follicular dendritic cells is normal or increased. Antibody to fascin-1 has been suggested as a prognostic marker in neuroendocrine neoplasms of the lung as well as in ovarian cancer. Fascin-1 expression may be induced by Epstein-Barr virus (EBV) infection of B cells with the possibility that viral induction of fascin in lymphoid or other cell types must also be considered in EBV-positive cases.

UniProt: Q16658