Fascin anticorps (AA 350-400)

N° du produit ABIN7874185

Cet anticorps anti-Fascin Monoclonal Souris (Clone FSCN1-7209) (ABIN7874185) détecte spécifiquement Fascin dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Fascin anticorps (AA 350-400) (ABIN7874185)

Antigène: Fascin (FSCN1)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Fascin est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: FSCN1-7209

Détail du produit anti-Fascin anticorps

Épitope: AA 350-400

Fonction: FSCN1 Antibody / Fascin 1 (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: A portion of amino acids 350-400 from the human FSCN1 protein was used as the immunogen for the FSCN1 antibody.

Isotype: IgG2a, kappa

Information d'application

Indications d'application: Optimal dilution of the FSCN1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the FSCN1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur Fascin

Antigène: Fascin (FSCN1)

Autre désignation: FSCN1

Sujet: Recognizes a protein of 55 kDa, which is identified as fascin-1. Its actin binding ability is regulated by phosphorylation. Antibody to fascin-1 is a very sensitive marker for Reed-Sternberg cells and variants in nodular sclerosis, mixed cellularity, and lymphocyte depletion Hodgkin s disease. It is uniformly negative in lymphoid cells, plasma cells, and myeloid cells. Fascin-1 is also expressed in dendritic cells. This marker may be helpful to distinguish between Hodgkin lymphoma and non-Hodgkin lymphoma in difficult cases. Also, the lack of expression of fascin-1 in the neoplastic follicles in follicular lymphoma may be helpful in distinguishing these lymphomas from reactive follicular hyperplasia in which the number of follicular dendritic cells is normal or increased. Antibody to fascin-1 has been suggested as a prognostic marker in neuroendocrine neoplasms of the lung as well as in ovarian cancer. Fascin-1 expression may be induced by Epstein-Barr virus (EBV) infection of B cells with the possibility that viral induction of fascin in lymphoid or other cell types must also be considered in EBV-positive cases.

UniProt: Q16658